急性缺血性卒中后的炎症反应。

Inflammatory response after acute ischemic stroke.

作者信息

Marquardt Lars, Ruf Andreas, Mansmann Ulrich, Winter Ralph, Buggle Florian, Kallenberg Kai, Grau Armin J

机构信息

Department of Neurology, Klinikum Ludwigshafen, Bremserstrasse 79, Ludwigshafen 67063, Germany.

出版信息

J Neurol Sci. 2005 Sep 15;236(1-2):65-71. doi: 10.1016/j.jns.2005.05.006.

DOI:10.1016/j.jns.2005.05.006

PMID:15961109

Abstract

BACKGROUND AND PURPOSE

This study aimed to characterize the time course of inflammatory parameters after acute ischemic stroke.

METHODS

We serially determined high sensitivity C-reactive protein (CRP), fibrinogen, and leukocyte counts at 10 time points between days 1 and 90 after ischemic stroke and in control subjects.

RESULTS

CRP did not significantly change, whereas fibrinogen increased after stroke. At all time points, CRP and fibrinogen were higher than in healthy control subjects, but not risk factor control subjects. The leukocyte count declined after stroke and was significantly elevated as compared to both control groups only on day 1 but not later. NIHSS levels were positively correlated with CRP and fibrinogen at all time points. Larger infarcts were associated with a higher CRP and leukocyte counts on day 90. Treatment with aspirin was associated with lower values for all three inflammatory parameters in the subacute phase after ischemia.

CONCLUSIONS

The course after stroke was different between the parameters of inflammation. Only the leukocytes followed the paradigm of an acute phase response.

摘要

背景与目的

本研究旨在描述急性缺血性卒中后炎症参数的时间进程。

方法

我们在缺血性卒中后第1天至第90天的10个时间点，对患者及对照受试者连续测定高敏C反应蛋白（CRP）、纤维蛋白原和白细胞计数。

结果

CRP无显著变化，而卒中后纤维蛋白原升高。在所有时间点，CRP和纤维蛋白原均高于健康对照受试者，但低于危险因素对照受试者。卒中后白细胞计数下降，仅在第1天与两个对照组相比显著升高，之后则无此现象。在所有时间点，美国国立卫生研究院卒中量表（NIHSS）水平与CRP和纤维蛋白原呈正相关。较大梗死灶与第90天较高的CRP和白细胞计数相关。缺血后亚急性期，阿司匹林治疗与所有三项炎症参数的较低值相关。