氯化铊-201（Tl-201）在头颈部肿瘤中的蓄积及钠钾ATP酶表达

Thallium-201 chloride (Tl-201) accumulation and Na+/K+-ATPase expression in tumours of the head and neck.

作者信息

Sato T, Indo H, Kawabata Y, Kobayashi T, Suenaga S, Iwashita Y, Nitta T, Sugihara K, Majima H J

机构信息

Department of Oncology, Maxillofacial Radiology Division, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, Japan.

出版信息

Dentomaxillofac Radiol. 2005 Jul;34(4):212-7. doi: 10.1259/dmfr/50773431.

DOI:10.1259/dmfr/50773431

PMID:15961594

Abstract

OBJECTIVES

The purpose of this report was to evaluate the relationship between the tumour retention index of thallium-201 chloride (Tl-201) scintigraphy and the Na+/K+-ATPase expression in tumours of the head and neck.

METHODS

Tl-201 scintigraphy was performed in 146 patients (129 with malignant tumours, ten with benign tumours and seven with inflammation). The tumour retention index was obtained from the early and delayed dynamic Tl-201 scans. The Na+/K+-ATPase expression was evaluated immunohistochemically in 61 of 129 patients with malignant tumour. Furthermore, another 22 patients with benign tumour were evaluated immunohistochemically as a benign control. Comparison of the correlations between the grade of histopathological differentiation of tumour, the tumour retention index of Tl-201 scintigraphy and the Na+/K+-ATPase expression was performed.

RESULTS

The grade of histopathological differentiation of tumour, the tumour retention index of Tl-201 scintigraphy and the expression of Na+/K+-ATPase showed a good correlation indicating that Na+/K+-ATPase plays an important role in transportation for Tl-201 to go through the tumour cell membrane.

CONCLUSIONS

Na+/K+-ATPase is one of the most important factors for Tl-201 accumulation in tumour.

摘要

目的

本报告旨在评估氯化铊（Tl-201）闪烁扫描的肿瘤滞留指数与头颈部肿瘤中Na+/K+-ATP酶表达之间的关系。

方法

对146例患者进行了Tl-201闪烁扫描（129例恶性肿瘤患者、10例良性肿瘤患者和7例炎症患者）。肿瘤滞留指数从早期和延迟动态Tl-201扫描中获得。对129例恶性肿瘤患者中的61例进行免疫组织化学评估Na+/K+-ATP酶表达。此外，另外22例良性肿瘤患者作为良性对照进行免疫组织化学评估。对肿瘤组织病理学分化程度、Tl-201闪烁扫描的肿瘤滞留指数和Na+/K+-ATP酶表达之间的相关性进行比较。