Nakamura K, Nishiguchi I, Takagi Y, Kubo A, Hashimoto S, Takami H
Radioisotopes. 1983 Dec;32(12):626-8.
Though the mechanism of 201Tl accumulation in thyroid tumours is not known yet, there are some hypotheses. In order to study the mechanism, potassium contents and Na, K-ATPase, of various organs of rats and human thyroid glands were analyzed . The conclusion through these experiments is as follows, 1 as the potassium contents and Na, K-ATPase activity of thyroid glands are not obviously higher than those of other organs, the 201Tl accumulation in thyroid is thought to be not owing to the similarity to the potassium ion, 2 pointing out high activity of Na, K-ATPase in heart and kidney, the accumulation mechanism of 201Tl in these organs has high relation to this activity, 3 though there is a tendency to have higher potassium contents among thyroid tumours, the difference in potassium contents between their histopathology is small; so that the tumour specificity is not explained from the potassium contents, and 4 as for Na, K-ATPase activity of thyroid tumours, papillary adenocarcinoma and follicular adenoma, which take more in 201Tl, have tendency to show higher activity; adenomatous goitre, which take less in 201Tl, has tendency to show lower activity. We suggested that the factor relating to the accumulation mechanism of 201Tl may be multiple, and Na, K-ATPase plays an important role in 201Tl specific uptake in thyroid tumours.
虽然201铊在甲状腺肿瘤中蓄积的机制尚不清楚，但有一些假说。为了研究其机制，对大鼠各器官及人甲状腺的钾含量和钠钾ATP酶进行了分析。通过这些实验得出的结论如下：1. 由于甲状腺的钾含量和钠钾ATP酶活性并不明显高于其他器官，因此认为201铊在甲状腺中的蓄积并非源于与钾离子的相似性；2. 指出心脏和肾脏中钠钾ATP酶活性较高，201铊在这些器官中的蓄积机制与该活性密切相关；3. 虽然甲状腺肿瘤之间钾含量有升高趋势，但其组织病理学之间的钾含量差异较小，因此无法从钾含量解释肿瘤特异性；4. 关于甲状腺肿瘤的钠钾ATP酶活性，摄取较多201铊的乳头状腺癌和滤泡性腺瘤往往表现出较高活性，摄取较少201铊的腺瘤性甲状腺肿则往往表现出较低活性。我们认为与201铊蓄积机制相关的因素可能是多方面的，钠钾ATP酶在甲状腺肿瘤对201铊的特异性摄取中起重要作用。
