科威特人群中红细胞同种抗体的频率。

Frequency of red blood cell alloantibody in Kuwaiti population.

作者信息

Ameen Reem, Al-Eyaadi Ohood, Al-Shemmari Salem, Chowdhury Rafiqul, Al-Bashir Abdulaziz

机构信息

Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait.

出版信息

Med Princ Pract. 2005 Jul-Aug;14(4):230-4. doi: 10.1159/000085740.

DOI:10.1159/000085740

PMID:15961931

Abstract

OBJECTIVE

The aim of this study was to analyze the alloimmunization against red blood cells (RBC) among Kuwaiti population.

MATERIALS AND METHODS

Retrospective analysis of RBC alloimmunization among 179,045 Kuwaiti patients, pregnant women, and allogeneic blood donors was conducted for the period of 1992-2001. The frequency of 24 alloantibody specificities from 1,278 alloimmunized Kuwaitis was estimated.

RESULTS

The prevalence of positive antibody screen in Kuwait was 0.49%. The five most frequently identified alloantibodies were anti-D (27.3%), anti-E (18.5%), anti-K (15.6%), anti-Le(a) (8.7%), and anti-Le(b) (6.6%). Frequency of alloimmunization was greater among Kuwaiti female than male patients (3.2 F to 1 M). Anti-D (p<0.001), anti-E (p=0.05), anti-K (p=0.04) were also more frequently identified alloantibody among Kuwaiti females.

CONCLUSION

The results show higher predominance of RBC alloimmunization in females than males. Anti-D, anti-E, and anti-K were the most common clinically significant alloantibodies identified in the Kuwaiti population and were also more frequent among Kuwaiti females.

摘要

目的

本研究旨在分析科威特人群中针对红细胞（RBC）的同种免疫情况。

材料与方法

对1992年至2001年期间179,045名科威特患者、孕妇和异体献血者的红细胞同种免疫情况进行回顾性分析。估计了1278名发生同种免疫的科威特人中24种同种抗体特异性的频率。

结果

科威特抗体筛查阳性率为0.49%。五种最常鉴定出的同种抗体为抗-D（27.3%）、抗-E（18.5%）、抗-K（15.6%）、抗-Le(a)（8.7%）和抗-Le(b)（6.6%）。科威特女性患者的同种免疫频率高于男性患者（女性与男性比例为3.2:1）。抗-D（p<0.001）、抗-E（p=0.05）、抗-K（p=0.04）在科威特女性中也是更常鉴定出的同种抗体。