病灶内注射博来霉素在复杂性血管瘤治疗中的作用：前瞻性临床研究
Role of intralesional bleomycin in the treatment of complicated hemangiomas: prospective clinical study.
作者信息
Omidvari Shapour, Nezakatgoo Nosrat, Ahmadloo Niloofar, Mohammadianpanah Mohammad, Mosalaei Ahmad
机构信息
Department of Radiation Oncology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Dermatol Surg. 2005 May;31(5):499-501. doi: 10.1111/j.1524-4725.2005.31150.
BACKGROUND
Hemangioma is the most common tumor of infancy. Although it has a basically benign nature and usually spontaneously regresses, a small percentage (5%) have complications that need treatment. Many different therapeutic modalities can be used in this tumor.
OBJECTIVE
To investigate the effect of a new method of treatment (intralesional bleomycin injection) in complicated hemangiomas.
MATERIALS AND METHODS
In the Department of Radiation Oncology at Nemazee Hospital in Shiraz, Iran, from April 1992 to October 1998, 32 patients with complicated hemangioma were treated with four to six courses of direct injection of bleomycin into the lesion.
RESULTS
After a minimum follow-up of 6 years, there was 70 to 100% regression in 18 patients, 50 to 70% in 7 cases, and less than 50% reduction in 7 patients.
CONCLUSION
Intralesional injection of bleomycin is an easy, safe, and effective therapeutic modality in complicated cutaneous hemangiomas.
背景
血管瘤是婴儿期最常见的肿瘤。尽管其本质上基本为良性且通常会自发消退，但仍有一小部分（5%）会出现需要治疗的并发症。针对这种肿瘤可以采用多种不同的治疗方式。
目的
研究一种新的治疗方法（瘤内注射博来霉素）对复杂性血管瘤的疗效。
材料与方法
在伊朗设拉子内马齐医院放射肿瘤科，从1992年4月至1998年10月，对32例复杂性血管瘤患者进行了四至六个疗程的博来霉素直接瘤内注射治疗。
结果
在至少6年的随访后，18例患者的血管瘤消退了70%至100%，7例患者消退了50%至70%，7例患者的消退率低于50%。
结论
瘤内注射博来霉素是治疗复杂性皮肤血管瘤的一种简便、安全且有效的治疗方式。
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