小鼠小脑神经元中纤维母细胞生长因子2（FGF-2）表达的年龄依赖性变化。
Age-dependent changes in Fibroblast growth factor 2 (FGF-2) expression in mouse cerebellar neurons.
作者信息
Reynolds J, Logan A, Berry M, Dent R G, Gonzales A M, Toescu E C
机构信息
Department of Medicine, Division of Medical Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom.
出版信息
J Cell Mol Med. 2005 Apr-Jun;9(2):398-406. doi: 10.1111/j.1582-4934.2005.tb00365.x.
Fibroblast growth factor 2 (FGF-2) is a neurotrophic factor that regulates many neuronal functions and survival. We have characterised FGF-2 expression immunohistochemically in the cerebellum of young (4 months) and old (22 months) mice. About half of the population of the granule cells (GC), and all Purkinje cells (PC) expressed FGF-2 in all folia of the cerebellum at both ages. FGF-2 showed differential intracellular localization: predominantly localised to the nuclei of GC and present mainly in the cytosol of PC. There was a statistically significant (P = 0.0028) reduction in the number of FGF-2-positive GC in the cerebella of old (41.3+/-0.91%) compared to young (48.5+/-1.67%) mice, whereas no statistically significant age-dependent difference occurred in the number of FGF-2 positive PC. These results indicate a possible role of FGF-2 in cerebellar ageing.
成纤维细胞生长因子2（FGF - 2）是一种神经营养因子，可调节多种神经元功能和神经元存活。我们已经通过免疫组织化学方法对年轻（4个月）和年老（22个月）小鼠小脑内的FGF - 2表达进行了表征。在两个年龄段小鼠的小脑所有小叶中，约一半的颗粒细胞（GC）群体以及所有浦肯野细胞（PC）均表达FGF - 2。FGF - 2显示出不同的细胞内定位：主要定位于GC的细胞核，主要存在于PC的细胞质中。与年轻小鼠（48.5±1.67%）相比，年老小鼠（41.3±0.91%）小脑中FGF - 2阳性GC的数量有统计学意义的减少（P = 0.0028），而FGF - 2阳性PC的数量没有统计学意义的年龄依赖性差异。这些结果表明FGF - 2在小脑衰老中可能发挥作用。
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