Carthew Richard W
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA.
Curr Opin Genet Dev. 2005 Aug;15(4):358-63. doi: 10.1016/j.gde.2005.06.002.
The adherens junction functions to connect epithelial cells and maintain their polarized architecture. The geometry of the adherens junction, and consequently the shape of a cell, appears to reach an energetically favorable state. Cadherins within the adherens junction are necessary for cells to achieve this state. However, the view of an adherens junction as a static structure is at odds with the highly dynamic properties of epithelia during development. Interactions between the actin cytoskeleton and the adherens junction are required for certain cell shape changes. Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction.
黏着连接的功能是连接上皮细胞并维持其极性结构。黏着连接的几何形状，进而细胞的形状，似乎会达到一种能量上有利的状态。黏着连接中的钙黏蛋白是细胞达到这种状态所必需的。然而，将黏着连接视为静态结构的观点与上皮细胞在发育过程中的高度动态特性不一致。肌动蛋白细胞骨架与黏着连接之间的相互作用是某些细胞形状变化所必需的。最近对黏着连接重塑的深入了解揭示了肌球蛋白和Par3在黏着连接处的极性定位的重要性。
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