Latham Zoe D, Bermudez Alexandra, Hu Jimmy K, Lin Neil Y C
Bioengineering Department, UCLA, Los Angeles, California 90095, USA.
Biophys Rev (Melville). 2024 Oct 14;5(4):041301. doi: 10.1063/5.0220088. eCollection 2024 Dec.
Multicellular systems, such as epithelial cell collectives, undergo transitions similar to those in inert physical systems like sand piles and foams. To remodel or maintain tissue organization during development or disease, these collectives transition between fluid-like and solid-like states, undergoing jamming or unjamming transitions. While these transitions share principles with physical systems, understanding their regulation and implications in cell biology is challenging. Although cell jamming and unjamming follow physics principles described by the jamming diagram, they are fundamentally biological processes. In this review, we explore how cellular processes and interactions regulate jamming and unjamming transitions. We begin with an overview of how these transitions control tissue remodeling in epithelial model systems and describe recent findings of the physical principles governing tissue solidification and fluidization. We then explore the mechanistic pathways that modulate the jamming phase diagram axes, focusing on the regulation of cell fluctuations and geometric compatibility. Drawing upon seminal works in cell biology, we discuss the roles of cytoskeleton and cell-cell adhesion in controlling cell motility and geometry. This comprehensive view illustrates the molecular control of cell jamming and unjamming, crucial for tissue remodeling in various biological contexts.
多细胞系统，如上皮细胞集合体，会经历与沙堆和泡沫等惰性物理系统类似的转变。为了在发育或疾病过程中重塑或维持组织结构，这些集合体会在类流体状态和类固体状态之间转变，经历堵塞或解堵塞转变。虽然这些转变与物理系统有共同的原理，但理解它们在细胞生物学中的调控及影响具有挑战性。尽管细胞堵塞和解堵塞遵循堵塞图所描述的物理原理，但它们从根本上来说是生物学过程。在这篇综述中，我们探讨细胞过程和相互作用如何调控堵塞和解堵塞转变。我们首先概述这些转变如何控制上皮模型系统中的组织重塑，并描述有关组织固化和流化的物理原理的最新发现。然后我们探索调节堵塞相图轴的机制途径，重点关注细胞波动和几何兼容性的调控。借鉴细胞生物学的开创性研究成果，我们讨论细胞骨架和细胞间粘附在控制细胞运动性和几何形状方面的作用。这种全面的观点阐明了细胞堵塞和解堵塞的分子调控，这对于各种生物学背景下的组织重塑至关重要。
