来自非洲中南部的布氏托达木（芸香科：托达木亚科）的N-取代吖啶酮生物碱。

N-Substituted acridone alkaloids from Toddaliopsis bremekampii (Rutaceae: Toddalioideae) of south-central Africa.

作者信息

Naidoo Dashnie, Coombes Philip H, Mulholland Dulcie A, Crouch Neil R, van den Bergh Albert J J

机构信息

School of Chemistry, University of KwaZulu-Natal, Howard College Campus, Durban 4041, South Africa.

出版信息

Phytochemistry. 2005 Jul;66(14):1724-8. doi: 10.1016/j.phytochem.2005.04.036.

DOI:10.1016/j.phytochem.2005.04.036

PMID:15964040

Abstract

Toddaliopsins A-D, four novel 1,2,3-trioxygenated acridone alkaloids, have been isolated from the leaves of Toddaliopsis bremekampii. Toddaliopsins B-D are the first reported acridone alkaloids with substituted N-methyl groups, in the light of which the chemotaxonomic relationship of Toddaliopsis and Vepris is discussed. Toddaliopsin C possesses moderate anti-inflammatory activity, which may be related to the hydroxy group present at C-1.

摘要

从短序豆叶中分离出了四种新型的1,2,3-三氧化吖啶酮生物碱——托达利奥辛A-D。托达利奥辛B-D是首次报道的带有取代N-甲基的吖啶酮生物碱，据此讨论了短序豆属与扁叶豆属的化学分类关系。托达利奥辛C具有中等抗炎活性，这可能与C-1位上存在的羟基有关。