来自非洲南部的杰氏特克莱木（芸香科：托达罗亚科）中的吖啶酮和呋喃喹啉生物碱。

Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa.

作者信息

Waffo Alain F Kamdem, Coombes Philip H, Crouch Neil R, Mulholland Dulcie A, El Amin Sawsan M M, Smith Peter J

机构信息

School of Chemistry, University of KwaZulu-Natal, Howard College Campus, 4041, Durban, South Africa.

出版信息

Phytochemistry. 2007 Mar;68(5):663-7. doi: 10.1016/j.phytochem.2006.10.011. Epub 2006 Dec 15.

DOI:10.1016/j.phytochem.2006.10.011

PMID:17174364

Abstract

The combined hexane/CH(2)Cl(2) extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.3 and 24.5 microM, respectively.

摘要

糙枝崖椒（芸香科：吴茱萸亚科）茎皮的己烷/二氯甲烷混合提取物已分离出两种吖啶酮生物碱，3-羟基-1-甲氧基-N-甲基吖啶酮（崖椒定A）（1）和3-羟基-N-甲基-1-（γ，γ-二甲基烯丙氧基）吖啶酮（崖椒定B）（2）、三种已知的吖啶酮（3 - 5）、两种已知的呋喃喹啉（6,7）以及吖啶酮前体崖椒酮（8）。乔木辛（3）和吴茱萸因（6）对恶性疟原虫的氯喹敏感D10株表现出中等程度的抗疟活性，IC50值分别为12.3和24.5微摩尔。