DNA修复：如何挑选一个合作伙伴。
DNA repair: how to PIKK a partner.
作者信息
Hiom Kevin
机构信息
Protein and Nucleic Acid Chemistry Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
出版信息
Curr Biol. 2005 Jun 21;15(12):R473-5. doi: 10.1016/j.cub.2005.06.012.
PMID:15964271
Abstract
In eukaryotes, members of the phosphoinositide-3-kinase-related protein kinase (PIKK) family co-ordinate the cellular response to DNA damage. But how do these important kinases detect DNA damage and relay this information to the DNA repair and checkpoint machinery?
摘要
在真核生物中，磷酸肌醇-3-激酶相关蛋白激酶（PIKK）家族的成员协调细胞对DNA损伤的反应。但是这些重要的激酶如何检测DNA损伤并将此信息传递给DNA修复和检查点机制呢？
Zotero 插件