利氏屏障：使用8周期间的阴道镜检查和微生物检测。
Lea's Shield: colposcopic and microbiological testing during 8 weeks of use.
作者信息
Mauck Christine K, Creinin Mitchell D, Rountree Wes, Callahan Marianne M, Hillier Sharon L
机构信息
CONRAD, Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Arlington, VA 22209, USA.
出版信息
Contraception. 2005 Jul;72(1):53-9. doi: 10.1016/j.contraception.2005.01.007.
OBJECTIVES
The aims of this study were to assess the effects of Lea's Shield(R) plus nonoxynol-9 spermicide on signs and symptoms of female genital irritation and cervical and vaginal microflora during 8 weeks of use with intercourse and to analyze problems associated with the use of the device.
METHODS
In this open-label, single-arm study, participants were evaluated by pelvic examination, colposcopy and vaginal and cervical cultures.
RESULTS
About 13% of women (4/30) reported symptoms of irritation, and minor product-related colposcopic findings were seen in about one third (11/30). Although average colony counts for enterococcus, Escherichia coli and anaerobic gram-negative rods increased during product use, no clinical diagnoses of infection were made. Most users reported at least one problem using Lea's Shield.
CONCLUSION
Lea's Shield, when used for 8 weeks during intercourse, is associated with evidence of genital irritation in a minority of users and with changes in vaginal microflora that do not appear to correlate with clinical infections.
目的
本研究旨在评估利阿护盾（Lea's Shield）加壬苯醇醚 - 9 杀精剂在性交时使用 8 周期间对女性生殖器刺激的体征和症状以及宫颈和阴道微生物群的影响，并分析与该装置使用相关的问题。
方法
在这项开放标签的单臂研究中，通过盆腔检查、阴道镜检查以及阴道和宫颈培养对参与者进行评估。
结果
约 13% 的女性（4/30）报告有刺激症状，约三分之一（11/30）出现与产品相关的轻微阴道镜检查结果。虽然在产品使用期间肠球菌、大肠杆菌和厌氧革兰氏阴性杆菌的平均菌落数增加，但未做出感染的临床诊断。大多数使用者报告在使用利阿护盾时至少出现一个问题。
结论
利阿护盾在性交时使用 8 周，少数使用者出现生殖器刺激迹象，且阴道微生物群发生变化，但这些变化似乎与临床感染无关。
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