盘基网柄菌中的发育决定

Developmental decisions in Dictyostelium discoideum.

作者信息

Strmecki Lana, Greene David M, Pears Catherine J

机构信息

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

出版信息

Dev Biol. 2005 Aug 1;284(1):25-36. doi: 10.1016/j.ydbio.2005.05.011.

DOI:10.1016/j.ydbio.2005.05.011

PMID:15964562

Abstract

Dictyostelium discoideum is an excellent system in which to study developmental decisions. Synchronous development is triggered by starvation and rapidly generates a limited number of cell types. Genetic and image analyses have revealed the elegant intricacies associated with this simple development system. Key signaling pathways identified as regulating cell fate decisions are likely to be conserved with metazoa and are providing insight into differentiation decisions under circumstances where considerable cell movement takes place during development.

摘要

盘基网柄菌是研究发育决策的绝佳系统。饥饿会触发其同步发育，并迅速产生有限数量的细胞类型。遗传分析和图像分析揭示了与这个简单发育系统相关的精妙复杂性。被确定为调节细胞命运决策的关键信号通路可能在后生动物中是保守的，并且为了解在发育过程中发生大量细胞移动的情况下的分化决策提供了思路。