一种新型口服尼古丁替代品减少中度吸烟者吸烟欲望的能力。

Ability of a new oral nicotine substitute to reduce smoking urge in moderate smokers.

作者信息

Demazières A, Luthringer R, Coppel E, Gilles C, Fleury C, Roegel J C, Delarue A, Laur C, Lagrue G

机构信息

FORENAP Research Institute for Neuroscience, Pharmacology and Psychiatry, 27 rue du 4eme RSM, 68250 Rouffach, France.

出版信息

Addict Behav. 2006 Mar;31(3):537-43. doi: 10.1016/j.addbeh.2005.05.017. Epub 2005 Jun 17.

DOI:10.1016/j.addbeh.2005.05.017

PMID:15964703

Abstract

The aim of this study was to assess the effectiveness of a new nicotine lozenge ( Nicopass 1.5 mg) in reducing smoking urge after an overnight abstinence. Twenty-four moderate smokers participated in a randomized, double-blind, placebo-controlled, 2-period crossover trial. The results showed that 1.5 mg-nicotine lozenge is superior to placebo in reducing smoking urge (p = 0.0001). In addition, nicotine lozenge, but not placebo, significantly improved vigilance and psychomotor performances (p < 0.05) and displayed a cardiac chronotropic effect. Thus, the 1.5-mg nicotine lozenge appears as an effective aid to alleviate acute tobacco withdrawal symptoms in moderate smokers.

摘要

本研究的目的是评估一种新型尼古丁含片（尼可帕斯1.5毫克）在夜间戒烟后减轻吸烟欲望的有效性。24名中度吸烟者参与了一项随机、双盲、安慰剂对照的两阶段交叉试验。结果显示，1.5毫克尼古丁含片在减轻吸烟欲望方面优于安慰剂（p = 0.0001）。此外，尼古丁含片而非安慰剂显著改善了警觉性和心理运动表现（p < 0.05），并显示出心脏变时效应。因此，1.5毫克尼古丁含片似乎是减轻中度吸烟者急性烟草戒断症状的有效辅助手段。