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[单侧系统性线状汗孔角化症。免疫组织化学和凝集素组织化学]

[Unilateral systematic linear porokeratosis. Immuno- and lectin histochemistry].

作者信息

Wollina U, Henkel U, Schaarschmidt H, Hipler C

机构信息

Klinik und Poliklinik für Hautkrankheiten, Medizinischen Fakultät, Friedrich-Schiller-Universität Jena, Deutschland.

出版信息

Zentralbl Pathol. 1992;138(1):51-4.

PMID:1596485
Abstract

An uncommon case of unilateral systemic linear porokeratosis in a women aged 22 years is reported in this paper. The results obtained from frozen-section investigations into lectin binding were indicative of reduced epidermal fucosylation and sialinization beneath the cornoid lamella. The basal stratum failed to react with a polyclonal antibody against calmodulin. Epidermal reaction, with AS-6 staining against urokinase, was of higher intensity. The above findings, as a whole, are likely to suggest accelerated keratinocyte migration to the stratum corneum in cases of linear porokeratosis and and should actually support assignment of the latter to the group of dermatoses with transepidermal elimination.

摘要

本文报道了一例22岁女性单侧系统性线状汗孔角化症的罕见病例。凝集素结合冰冻切片研究结果表明,角质层下表皮岩藻糖基化和唾液酸化减少。基底层未能与抗钙调蛋白的多克隆抗体发生反应。用抗尿激酶的AS-6染色显示表皮反应强度更高。总体而言,上述发现可能提示线状汗孔角化症病例中角质形成细胞向角质层的迁移加速,实际上也支持将其归为经表皮消除性皮肤病组。

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