Mailleret L, Gouzé J-L, Bernard O
Comore, Inria, BP93, 06902 Sophia-Antipolis cedex, France.
Bioprocess Biosyst Eng. 2005 Aug;27(5):319-27. doi: 10.1007/s00449-005-0410-8. Epub 2005 Jun 18.
This paper deals with output feedback control of phytoplanktonic algae growth models in the chemostat. The considered class of model is of variable yield type, meaning that the ratio between the environmental nutrient absorption rate and the cells' growth rate varies, which is different from classical bioprocesses assumptions. On the basis of weak qualitative hypotheses on the analytical expressions of the involved biological phenomena (which guarantee robustness of the procedure toward modeling uncertainties) we propose a nonlinear controller and prove its ability to globally stabilize such processes. Finally, we illustrate our approach with numerical simulations and show its benefits for biological laboratory experiments, especially for ensuring persistence of the culture facing classical experimental problems.
本文研究了恒化器中浮游藻类生长模型的输出反馈控制。所考虑的模型类别为可变产量类型,即环境养分吸收速率与细胞生长速率之间的比率是变化的,这与经典生物过程假设不同。基于对所涉及生物现象解析表达式的弱定性假设(这保证了该方法对建模不确定性的鲁棒性),我们提出了一种非线性控制器,并证明了其全局稳定此类过程的能力。最后,我们通过数值模拟说明了我们的方法,并展示了其在生物实验室实验中的优势,特别是在面对经典实验问题时确保培养物的持续性方面。