Wolff M, Hirner A
Klinik und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefässchirurgie, Rheinische Friedrich-Wilhelms-Universität, Bonn.
Zentralbl Chir. 2005 Jun;130(3):238-45. doi: 10.1055/s-2005-836545.
A switch to decompressive shunt procedures is mandatory if endoscopic therapy fails to control recurrent variceal hemorrhage. Surgical shunt procedures continue to be safe, highly effective and durable procedures to control variceal bleeding in patients with low operative risk and good liver function (Child A). In cirrhotics, elective operations using portal flow preserving techniques such as a selective distal splenorenal shunt (Warren) or a partial portocaval small diameter interposition shunt (Sarfeh) should be preferred. Rarely, end-to-side portocaval shunt may serve as a salvage procedure if emergent endoscopic treatment or TIPS insertion fail to stop bleeding. Until definitive results from randomized trials are available patients with good prognosis (Child-Pugh A and B) can be regarded as candidates for surgical shunts. For patients with noncirrhotic portal hypertension, in particular with extrahepatic portal vein thrombosis, portosystemic shunt surgery represents the only effective therapy which leads to freedom of recurrent bleeding and repeated endoscopies for many years, and improves hypersplenism without deteriorating liver function or encephalopathy. Gastroesophageal devascularization and other direct variceal ablative procedures should be restricted to treat endoscopic therapy failures without shuntable portal tributaries.
如果内镜治疗无法控制复发性静脉曲张出血,则必须改用减压分流术。手术分流术对于手术风险低且肝功能良好(Child A级)的患者而言,仍然是控制静脉曲张出血安全、高效且持久的方法。对于肝硬化患者,应首选采用保留门静脉血流技术的选择性手术,如选择性远端脾肾分流术(Warren术)或部分门腔小口径搭桥分流术(Sarfeh术)。极少情况下,如果紧急内镜治疗或经颈静脉肝内门体分流术(TIPS)未能止血,端侧门腔分流术可作为挽救性手术。在随机试验得出明确结果之前,预后良好(Child-Pugh A级和B级)的患者可被视为手术分流的候选者。对于非肝硬化门静脉高压患者,尤其是肝外门静脉血栓形成患者,门体分流手术是唯一有效的治疗方法,可使患者多年内不再反复出血和接受重复内镜检查,并改善脾功能亢进,而不会恶化肝功能或引发肝性脑病。胃食管去血管化和其他直接的静脉曲张消融手术应仅限于治疗内镜治疗失败且无可分流门静脉分支的患者。