Caputi Mario, Russo Giuseppe, Esposito Vincenzo, Mancini Alessandro, Giordano Antonio
Department of Cardio-Thoracic Sciences, II University of Naples, Naples, Italy.
J Cell Physiol. 2005 Dec;205(3):319-27. doi: 10.1002/jcp.20424.
Lung cancer is the leading cause of cancer death worldwide. Histologically, 80% of lung cancers are classified as non-small-cell lung cancer (NSCLC), and the remaining 20% as small-cell lung cancer (SCLC). Lung carcinoma is the result of molecular changes in the cell, resulting in the deregulation of pathways controlling normal cellular growth, differentiation, and apoptosis. This review summarizes some of the most recent findings about the role of cell-cycle proteins in lung cancer pathogenesis and progression.
肺癌是全球癌症死亡的主要原因。从组织学上看，80%的肺癌被归类为非小细胞肺癌（NSCLC），其余20%为小细胞肺癌（SCLC）。肺癌是细胞分子变化的结果，导致控制正常细胞生长、分化和凋亡的信号通路失调。本文综述了细胞周期蛋白在肺癌发病机制和进展中作用的一些最新研究结果。
