体细胞和胚胎干细胞中从G1期到S期的细胞周期转变。
G1 to S phase cell cycle transition in somatic and embryonic stem cells.
作者信息
Neganova Irina, Lako Majlinda
机构信息
North East Institute for Stem Cell Research, University of Newcastle upon Tyne, International Centre for Life, Newcastle NE1 3BZ, UK
出版信息
J Anat. 2008 Jul;213(1):30-44. doi: 10.1111/j.1469-7580.2008.00931.x.
Abstract
It is well known that G1 to S phase transition is tightly regulated by the expression and phosphorylation of a number of well-characterized cyclins, cyclin-dependent kinases and members of the retinoblastoma gene family. In this review we discuss the role of these components in regulation of G1 to S phase transition in somatic cells and human embryonic stem cells. Most importantly, we discuss some new tenable links between maintenance of pluripotency and cell cycle regulation in embryonic stem cells by describing the role that master transcription factors play in this process. Finally, the differences in cell cycle regulation between murine and human embryonic stem cells are highlighted, raising interesting questions regarding their biology and stages of embryonic development from which they have been derived.
摘要
众所周知，G1期到S期的转换受到多种已明确的细胞周期蛋白、细胞周期蛋白依赖性激酶以及视网膜母细胞瘤基因家族成员的表达和磷酸化的严格调控。在本综述中，我们讨论了这些成分在体细胞和人类胚胎干细胞中G1期到S期转换调控中的作用。最重要的是，我们通过描述主要转录因子在此过程中的作用，讨论了胚胎干细胞多能性维持与细胞周期调控之间一些新的合理联系。最后，强调了小鼠和人类胚胎干细胞在细胞周期调控方面的差异，这引发了关于它们的生物学特性以及所源自的胚胎发育阶段的有趣问题。
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