Arnulf Isabelle, Mabrouk Tarek, Mohamed Khalil, Konofal Eric, Derenne Jean-Philippe, Couratier Philippe
Fédération des Pathologies du Sommeil, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
Mov Disord. 2005 Sep;20(9):1223-8. doi: 10.1002/mds.20517.
A 55-year-old woman with a progressive dementia and frontal syndrome was hospitalized because she was agitated every night after falling asleep (spoke, laughed, cried, tapped, kicked, walked, and fell down). She slept 5.5 hours during video polysomnography, but the theta rhythm electroencephalograph recording typical of sleep stages 1 to 2 and the spindles and K-complexes typical of sleep stage 2 contrasted with continuous muscular twitching, prominent rapid eye movements, vocalizations, and continuous, complex, purposeful movements typical of rapid eye movement (REM) sleep behavior disorder. This newly described stages 1--2 non-REM sleep behavior disorder suggests that central motor pattern generators were disinhibited during non-REM sleep.
一名患有进行性痴呆和额叶综合征的55岁女性因入睡后每晚烦躁不安（说话、大笑、哭泣、轻拍、踢腿、行走和摔倒）而住院。在视频多导睡眠图监测期间，她睡了5.5小时，但脑电图记录显示出1至2期睡眠典型的θ节律以及2期睡眠典型的纺锤波和K复合波，这与持续的肌肉抽搐、明显的快速眼动、发声以及快速眼动（REM）睡眠行为障碍典型的持续、复杂、有目的的动作形成了对比。这种新描述的1-2期非快速眼动睡眠行为障碍表明，中枢运动模式发生器在非快速眼动睡眠期间被去抑制。
