Adachi Koko, Yamamoto Yoko, Kameyama Eri, Suzuki Hirotoshi, Horinouchi Takashi
Department of Anesthesiology, Tohoku University Graduate School of Medicine, Sendai.
Masui. 2005 Jun;54(6):653-7.
Moyamoya disease is a rare neurovascular disorder that requires special anesthetic managements during revascularization procedures. We have investigated the incidence of early postoperative complications under inhaled anesthesia in comparison with total intravenous anesthesia (TIVA) retrospectively.
Seventy-two patients undergoing revascularization procedures were divided into two groups, one with inhaled anesthesia (n = 23) and the other with TIVA (n = 49). Surgical procedures were performed under normocapnia, proper body temperature, and all patients were prevented from anemia by homologous transfusion. To avoid the variance in anesthetic managements, 39 patients under 15 years of age were picked up and divided in the same way as above. Early postoperative complications including transient ischemic attack and cerebral infarction during the first 2 weeks after operation were investigated.
In all patients, early postoperative complications occurred in 48% of inhaled anesthesia group and in 49% of TIVA group. In patients under 15, these complications occurred in 44% and in 57%, respectively. There was no significant difference in the incidence of complications between the two anesthetic groups.
Several previous studies reported the excellence of TIVA for revascularization procedure on the basis of regional blood flow because inhaled anesthesia may provoke intracerebral steal in moyamoya disease. Our investigation in this study revealed that both anesthetic methods have no significant difference in postoperative complications during the first 2 weeks after operation. Thus further study should be needed to verify the safety of inhalation anesthetics in patients with moyamoya disease.
烟雾病是一种罕见的神经血管疾病,在血运重建手术期间需要特殊的麻醉管理。我们回顾性研究了与全静脉麻醉(TIVA)相比,吸入麻醉下术后早期并发症的发生率。
72例行血运重建手术的患者被分为两组,一组采用吸入麻醉(n = 23),另一组采用TIVA(n = 49)。手术在正常碳酸血症、适当体温下进行,所有患者均通过同种异体输血预防贫血。为避免麻醉管理的差异,选取39例15岁以下患者并按上述方法分组。调查术后早期并发症,包括术后前2周内的短暂性脑缺血发作和脑梗死。
在所有患者中,吸入麻醉组术后早期并发症发生率为48%,TIVA组为49%。在15岁以下患者中,这些并发症发生率分别为44%和57%。两组麻醉方法的并发症发生率无显著差异。
此前多项研究基于局部血流情况报道了TIVA在血运重建手术中的优势,因为吸入麻醉可能会引发烟雾病患者的脑内盗血现象。我们在本研究中的调查显示,两种麻醉方法在术后前2周的并发症方面无显著差异。因此,需要进一步研究以验证吸入麻醉药对烟雾病患者的安全性。