Gonen E, Sahin I, Ozbek M, Kovalak E, Yologlu S, Ates Y
SSK Ankara Hospital, Orthopedics, Ankara, Turkey.
J Endocrinol Invest. 2005 Apr;28(4):322-6. doi: 10.1007/BF03347197.
The aim of this study was to evaluate the net changes in bone mineral density (BMD) during the reproductive cycle, and their relation with changes in serum calcium (Ca), phosphorus (P), PTH and calcitonin levels in rats. Twenty-seven female Wistar rats were included in this study. They were divided into three groups as pregnant, lactating and control groups. BMDs of lumbar vertebrates, femoral and tibial bones, and Ca, P, calcitonin and PTH levels were measured at the end of pregnancy, at the end of lactation and in nulliparous controls. In the pregnant group, the BMDs of rats were significantly higher in lumbar vertebrates, femoral and tibia bones than those of the control group (p<0.05). Their PTH and Ca levels were significantly lower than the control group (p<0.05). However, no statistically significant difference was found regarding P and calcitonin levels when compared to those of the control group. In the lactating group, the BMDs were significantly lower in lumbar vertebrates, femoral and tibia bones than those seen in the control and pregnant groups (p<0.05). Ca and PTH levels were significantly higher in lactating rats than in those of pregnant rats (p<0.005). Normal pregnancy increases BMD in rats, whereas lactation decreases it. Change in PTH levels is supposed to contribute to the mineralization and demineralization of the skeleton during pregnancy and lactation, respectively.
本研究的目的是评估大鼠生殖周期中骨矿物质密度（BMD）的净变化，以及它们与血清钙（Ca）、磷（P）、甲状旁腺激素（PTH）和降钙素水平变化的关系。本研究纳入了27只雌性Wistar大鼠。它们被分为三组：怀孕组、哺乳组和对照组。在怀孕末期、哺乳末期和未生育的对照组中测量腰椎、股骨和胫骨的骨密度，以及Ca、P、降钙素和PTH水平。在怀孕组中，大鼠腰椎、股骨和胫骨的骨密度显著高于对照组（p<0.05）。它们的PTH和Ca水平显著低于对照组（p<0.05）。然而，与对照组相比，P和降钙素水平没有统计学上的显著差异。在哺乳组中，腰椎、股骨和胫骨的骨密度显著低于对照组和怀孕组（p<0.05）。哺乳大鼠的Ca和PTH水平显著高于怀孕大鼠（p<0.005）。正常怀孕会增加大鼠的骨密度，而哺乳则会降低骨密度。PTH水平的变化分别被认为有助于怀孕和哺乳期间骨骼的矿化和脱矿作用。
