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波多黎各门诊精神病学实践中重度抑郁发作患者对躯体症状的识别水平:一项观察性研究。

The level of recognition of physical symptoms in patients with a major depression episode in the outpatient psychiatric practice in Puerto Rico: an observational study.

作者信息

Tamayo Jorge M, Román Karis, Fumero Juan J, Rivas María

机构信息

Lilly Research Laboratories, Eli Lilly and Company, San Juan, Puerto Rico.

出版信息

BMC Psychiatry. 2005 Jun 20;5:28. doi: 10.1186/1471-244X-5-28.

Abstract

BACKGROUND

This study was designed to evaluate the psychiatrists' level of recognition of somatic symptoms associated to a major depressive episode (MDE) (DSM-IV-TR criteria) and the impact of those somatic symptoms on the treatment effectiveness.

METHODS

This non-interventional study was conducted in 25 medical offices in Puerto Rico from February to December 2003. It had 2 visits separated by 8 weeks. The level of recognition was determined by: the correlation between the physician clinical evaluation and their patients' self-evaluations through different validated instruments using kappa statistics. Chi-square test was used to evaluate the impact of somatic symptoms on treatment antidepressants' effectiveness.

RESULTS

All the 145 recruited patients reported the presence of at least one somatic symptom associated with their current MDE. In the two visits covered by the study, a fair agreement between the psychiatrists' and the patients' reports was noted for headache, abdominal pain and upper limb pains (0.4003 <or= kappa >or= 0.6594). For other painful symptoms and painless somatic symptoms, the Kappa values obtained were non-significant. Slight but significant reductions in depression and painful symptoms severity were observed after 8 weeks of treatment. A proportional relationship between the pain and depression severity was observed (p < 0.0001).

CONCLUSION

The study results show that somatic symptoms: are very common in depressed Puerto Rican patients; are significant under-reported by psychiatrists; and have a significant impact on the antidepressant effectiveness.

摘要

背景

本研究旨在评估精神科医生对与重度抑郁发作(MDE,依据《精神疾病诊断与统计手册》第四版修订版标准)相关的躯体症状的识别水平,以及这些躯体症状对治疗效果的影响。

方法

这项非干预性研究于2003年2月至12月在波多黎各的25个医疗机构开展。研究分为两次就诊,间隔8周。识别水平通过以下方式确定:使用kappa统计量,通过不同经过验证的工具,分析医生临床评估与患者自我评估之间的相关性。采用卡方检验评估躯体症状对抗抑郁药治疗效果的影响。

结果

所有145名招募的患者均报告存在至少一种与其当前MDE相关的躯体症状。在研究涵盖的两次就诊中,对于头痛、腹痛和上肢疼痛,精神科医生与患者报告之间存在中等程度的一致性(0.4003≤kappa≤0.6594)。对于其他疼痛症状和无痛性躯体症状,获得的Kappa值无统计学意义。治疗8周后,观察到抑郁和疼痛症状严重程度有轻微但显著的降低。观察到疼痛与抑郁严重程度之间存在比例关系(p<0.0001)。

结论

研究结果表明,躯体症状:在波多黎各抑郁患者中非常常见;精神科医生对其报告明显不足;并且对抗抑郁药疗效有显著影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d8f/1183226/41a1bacde637/1471-244X-5-28-1.jpg

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