慢性炎症性脱髓鞘性多发性神经根神经病中的膀胱和肠道功能障碍

Bladder and bowel dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy.

作者信息

Ishii Kazuhiro, Tamaoka Akira, Fujita Youshi, Shoji Shin'ichi

机构信息

Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Ten'noudai, Tsukuba-shi, Ibaraki-ken, 305-8575, Japan.

出版信息

Eur J Intern Med. 2005 Jun;16(3):211-213. doi: 10.1016/j.ejim.2004.10.021.

DOI:10.1016/j.ejim.2004.10.021

PMID:15967342

Abstract

We present a patient with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) who developed severe bladder and bowel dysfunction (BBD) as evidenced by constipation, voiding difficulty, and urinary urgency. These symptoms appeared 10 years after onset of CIDP. Cystometry showed disturbance of bladder sensation and detrusor areflexia. Magnetic resonance imaging (MRI) showed greatly enlarged nerve roots filling the lumbosacral spinal canal; this appeared to be the likely cause of BBD. A 3-day course of intravenous methylprednisolone (1 g/day), followed by 30 mg/day of oral prednisolone, ameliorated the sensory disturbance and muscle weakness, but not BBD.

摘要

我们报告一例慢性炎症性脱髓鞘性多发性神经根神经病（CIDP）患者，该患者出现了严重的膀胱和肠道功能障碍（BBD），表现为便秘、排尿困难和尿急。这些症状在CIDP发病10年后出现。膀胱测压显示膀胱感觉障碍和逼尿肌无反射。磁共振成像（MRI）显示腰骶部椎管内神经根明显增粗；这似乎是BBD的可能原因。静脉注射甲泼尼龙（1 g/天）3天疗程，随后口服泼尼松龙30 mg/天，改善了感觉障碍和肌肉无力，但未改善BBD。