McKenna Michael, Kenny Brian, Dorman Gary, McCluggage W Glenn
Department of Pathology, Royal Group of Hospitals Trust, Belfast BT12 6BL, Northern Ireland.
Int J Gynecol Pathol. 2005 Jul;24(3):224-7. doi: 10.1097/01.pgp.0000158532.90747.e7.
We describe an unusual ovarian neoplasm in a 57-year-old woman composed of an admixture of mucinous cystadenoma and adult granulosa cell tumor (AGCT). In areas the two components were separate but elsewhere there was intermingling of the two elements. The combination of mucinous cystadenoma and AGCT has only rarely been reported. Theories of histogenesis include a collision tumor and heterologous mucinous differentiation within an AGCT. We favor the latter theory in this case, because in many areas there was an intimate admixture of the two components. Because heterologous mucinous elements are well described in other ovarian sex-cord-stromal neoplasms, especially but not exclusively Sertoli Leydig cell tumors, it is not unexpected that a similar phenomenon could occur in an AGCT. We review the previously reported cases of combined mucinous cystadenoma and granulosa cell tumor of the ovary.
我们描述了一名57岁女性的一种罕见卵巢肿瘤,其由黏液性囊腺瘤和成人颗粒细胞瘤(AGCT)混合而成。在某些区域,这两种成分是分开的,但在其他地方,两种成分相互交织。黏液性囊腺瘤和AGCT的组合仅有极少的报道。组织发生学理论包括碰撞瘤以及AGCT内的异源性黏液分化。在这个病例中我们支持后一种理论,因为在许多区域两种成分紧密混合。由于在其他卵巢性索间质肿瘤中,尤其是但不限于支持-莱迪希细胞瘤中,异源性黏液成分已有充分描述,所以AGCT中出现类似现象并不意外。我们回顾了先前报道的卵巢黏液性囊腺瘤和颗粒细胞瘤合并的病例。