Unal Ethem, Uzun Hafize, Kusaslan Ramazan, Dogan Mustafa, Genc Habibe, Gunes Pembegul, Titiz Izzet
Department of Surgery, Haydarpasa Numune Research and Training Hospital, Haydarpasa, Istanbul, Turkey.
Pancreas. 2005 Jul;31(1):84-7. doi: 10.1097/01.mpa.0000168227.74203.e4.
This study was designed to determine the serum lipid profile and the activity of paraoxonase (PON1, the lipophilic antioxidant component of high-density lipoprotein [HDL]-cholesterol) in acute pancreatitis.
Acute pancreatitis was induced by injection of ethyl alcohol into the common biliary duct. Oxidative stress marker (malonyldialdehyde), lipid profile, and PON1 activity were determined in the serum.
In the acute pancreatitis group, whereas the mean levels of total cholesterol, low-density lipoproteins, and malonyldialdehyde were significantly higher (P < 0.001 for each), HDL level and PON1 activity were found to be significantly lower (P < 0.001 for each).
Our results suggest that an abnormal lipid profile and decreased PON1 activity may have a role in the pathogenesis of acute pancreatitis in which HDL-associated antioxidant defense is impaired.
本研究旨在测定急性胰腺炎患者的血脂谱以及对氧磷酶1（PON1，高密度脂蛋白[HDL]胆固醇的亲脂性抗氧化成分）的活性。
通过向胆总管注射乙醇诱导急性胰腺炎。测定血清中的氧化应激标志物（丙二醛）、血脂谱和PON1活性。
在急性胰腺炎组中，总胆固醇、低密度脂蛋白和丙二醛的平均水平显著更高（每项P < 0.001），而HDL水平和PON1活性显著更低（每项P < 0.001）。
我们的结果表明，血脂谱异常和PON1活性降低可能在急性胰腺炎的发病机制中起作用，其中与HDL相关的抗氧化防御受损。
