Fast high-resolution T1 mapping of the human brain.

A sequence for the acquisition of high-resolution T1 maps, based on magnetization-prepared multislice fast low-angle shot (FLASH) imaging, is presented. In contrast to similar methods, no saturation pulses are used, resulting in an increased dynamic range of the relaxation process. Furthermore, it is possible to acquire data during all relaxation delays because only slice-selective radiofrequency (RF) pulses are used for inversion and excitation. This allows for a reduction of the total acquisition time, or scanning with a reduced bandwidth, which improves the signal-to-noise ratio (SNR). The method generates quantitative T1 maps with an in-plane resolution of 1 mm, slice thickness of 4 mm, and whole-brain coverage in a clinically acceptable imaging time of about 19 s per slice. It is shown that the use of off-center RF pulses does not result in imperfect inversion or magnetization transfer (MT) effects. In addition, an improved fitting algorithm based on smoothed flip angle maps is presented and tested successfully.