癌症化疗前进行精子冷冻保存有助于在与癌症的情感斗争中发挥作用。

Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer.

作者信息

Saito Kazuo, Suzuki Kotaro, Iwasaki Akira, Yumura Yasushi, Kubota Yoshinobu

机构信息

Department of Urology and Kidney Transplantation, Yokohama City University Medical Center, 4-57 Urafune, Minami-ku, Yokohama, Kanagawa 232-0024, Japan.

出版信息

Cancer. 2005 Aug 1;104(3):521-4. doi: 10.1002/cncr.21185.

DOI:10.1002/cncr.21185

PMID:15968690

Abstract

BACKGROUND

Sperm cryopreservation before cancer chemotherapy is available for young patients with cancer. However, few patients bank their sperm. The authors evaluated by questionnaire the psychological impact of sperm cryopreservation.

METHODS

The authors cryopreserved the sperm of 111 patients with cancer for free at the Yokohama City University (Yokohama, Japan). For the current study, questionnaires were mailed to 66 patients whose sperm had been cryopreserved. Fifty-one patients (77.3%) with testicular carcinomas (n = 24), leukemia or malignant lymphoma (n = 19), or other cancers (n = 8) answered the questionnaire. The average age at collection and the period of sperm cryopreservation were 30.1 +/- 6.0 (mean +/- standard deviation) and 3.3 +/- 2.2 years, respectively.

RESULTS

Many patients were informed of the deleterious effects of cancer chemotherapy and worried about infertility in the future. However, only half of the patients banked their sperm on their own initiative. Other patients followed their physician's instruction. Eighty percent of patients replied that sperm cryopreservation helped in the battle against cancer. Sperm banking especially was found to encourage every patient who banked sperm on their own initiative. After cancer chemotherapy, 70% of patients wanted to have a child. However, 60% of patients were worried about infertility in spite of having their sperm cryopreserved. No patients wanted to use cryopreserved sperm for fathering children if their spermatogenesis was restored. Sperm cryopreservation invigorated many patients with cancer after cancer treatments. The majority of patients recommended sperm cryopreservation to other cancer patients.

CONCLUSIONS

Sperm cryopreservation encouraged young patients with cancer during and after cancer treatment. It should be recommended for all young patients with cancer. However, sperm cryopreservation did not eliminate their fear of infertility.

摘要

背景

对于年轻癌症患者，在癌症化疗前可进行精子冷冻保存。然而，很少有患者储存精子。作者通过问卷调查评估了精子冷冻保存的心理影响。

方法

作者在日本横滨市立大学为111例癌症患者免费冷冻保存精子。在本研究中，向66例精子已被冷冻保存的患者邮寄了问卷。51例（77.3%）患有睾丸癌（n = 24）、白血病或恶性淋巴瘤（n = 19）或其他癌症（n = 8）的患者回答了问卷。采集时的平均年龄和精子冷冻保存时间分别为30.1±6.0（均值±标准差）岁和3.3±2.2年。

结果

许多患者了解到癌症化疗的有害影响，并担心未来不育。然而，只有一半的患者主动储存精子。其他患者听从医生的建议。80%的患者回答精子冷冻保存有助于抗癌。尤其发现精子储存鼓励了每一位主动储存精子的患者。癌症化疗后，70%的患者想要孩子。然而，尽管精子已被冷冻保存，仍有60%的患者担心不育。如果精子发生恢复，没有患者想用冷冻保存的精子生育孩子。精子冷冻保存在癌症治疗后使许多癌症患者振作起来。大多数患者向其他癌症患者推荐精子冷冻保存。