Ginsberg Jill P, Ogle Susan K, Tuchman Lisa K, Carlson Claire A, Reilly Maureen M, Hobbie Wendy L, Rourke Mary, Zhao Huaqing, Meadows Anna T
Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Pediatr Blood Cancer. 2008 Mar;50(3):594-8. doi: 10.1002/pbc.21257.
Infertility is often a complication for adolescent and young adult males who receive cancer therapy, a problem that might be averted through using cryopreserved sperm. We aim to evaluate feasibility of offering newly diagnosed patients the opportunity to bank sperm and, to determine the beliefs and decision-making processes of patients and their parents who considered sperm banking.
Eligible patients and parents were approached and offered sperm cryopreservation. Semen samples from patients who sequentially attempted sperm banking were analyzed. Questionnaires were then administered to patients and parents who had been approached about sperm banking.
Semen samples from 68 patients were analyzed. Nine patients were azoospermic; all had been pre-treated with chemotherapy. Fifty patients completed the questionnaire. Parent and patient made the decision together to bank 80% of the time. All sons who attempted to bank and their parents felt they had made the right decision, including those who attempted but failed.
Viable sperm can be collected successfully from adolescent and young adults who are newly diagnosed with cancer. Semen quality was dramatically reduced by one course of gonadotoxic therapy. Parents and patients want information regarding sperm cryopreservation early. Parents appear to play an important role in the decision to sperm bank. We recommend sperm banking be offered to all eligible patients.
对于接受癌症治疗的青少年和年轻成年男性而言，不孕往往是一种并发症，而通过使用冷冻保存的精子，这一问题或许可以避免。我们旨在评估为新诊断患者提供精子储存机会的可行性，并确定考虑进行精子储存的患者及其父母的信念和决策过程。
我们联系了符合条件的患者及其父母，并为他们提供精子冷冻保存服务。对依次尝试进行精子储存的患者的精液样本进行了分析。随后，我们向那些被联系过精子储存事宜的患者及其父母发放了问卷。
对68名患者的精液样本进行了分析。9名患者无精子；他们均接受过化疗预处理。50名患者完成了问卷。父母和患者共同做出精子储存决定的情况占80%。所有尝试进行精子储存的儿子及其父母都觉得他们做出了正确的决定，包括那些尝试但失败的人。
可以成功地从新诊断为癌症的青少年和年轻成年人身上采集到有活力的精子。一个疗程的性腺毒性治疗会使精液质量大幅下降。父母和患者希望尽早获得有关精子冷冻保存的信息。父母在精子储存的决定中似乎起着重要作用。我们建议为所有符合条件的患者提供精子储存服务。
