Gajwani Prashant, Forsthoff Anna, Muzina David, Amann Benedikt, Gao Keming, Elhaj Omar, Calabrese Joseph R, Grunze Heinz
NIMH Bipolar Research Center, Case Western Reserve University School of Medicine, Mood Disorders Program, University Hospitals of Cleveland, OH, USA.
Epilepsia. 2005;46 Suppl 4:38-44. doi: 10.1111/j.1528-1167.2005.463008.x.
Bipolar disorder is a common, recurrent, often severe mental disorder that, without adequate treatment, is associated with high rates of morbidity and mortality. We review the evidence on the efficacy of a spectrum of antiepileptic drugs (AED) in bipolar disorder. Most studies have been carried out with carbamazepine (CBZ), valproate (VPA), and lamotrigine (LTG). All three of these AEDs have been shown to be of value in the management of patients with bipolar illnesses. VPA and CBZ seem to exert stronger antimanic effects and, to a lesser degree, acute antidepressant efficacy. LTG seems to be effective against depression and mania, with a more robust activity against depression. No firm evidence supports a role for vigabatrin, tiagabine, topiramate, or levetiracetam in these disorders.
双相情感障碍是一种常见的、复发性的、通常较为严重的精神障碍，若未得到充分治疗，会导致高发病率和死亡率。我们综述了一系列抗癫痫药物（AED）治疗双相情感障碍疗效的证据。大多数研究是针对卡马西平（CBZ）、丙戊酸盐（VPA）和拉莫三嗪（LTG）进行的。这三种AED均已被证明在双相情感障碍患者的治疗中具有价值。VPA和CBZ似乎具有更强的抗躁狂作用，在较小程度上也有急性抗抑郁疗效。LTG似乎对抑郁和躁狂均有效，对抑郁的作用更强。没有确凿证据支持氨己烯酸、噻加宾、托吡酯或左乙拉西坦在这些疾病中的作用。
