Peng Li, Xu Zhi-Nan, Fang Xiang-Ming, Qu Jin-Min, Cen Pei-Lin
Institute of Bioengineering, Zhejiang University, Hangzhou 310027, China.
Sheng Wu Gong Cheng Xue Bao. 2003 May;19(3):261-6.
Human defensin is a family of cationic antimicrobial peptides in human being. During the last two decades a series of endogenous alpha-and beta-human defensins have been discovered. They are important components of the first barrier in human's body against the invasion of various microorganisms, and they are thought to play an important role in linking the innate and adaptive defense system of human being. The recent advances in the research of human defensins were reviewed, including their discovery, molecular and genetic properties, expression regulation, and mechanisms of antimicrobial activity. The possibility to produce human defensins via genetic engineering was also discussed. And the application outlook of human defensins in medicine and curing patients infected with antibiotics-resistant microbials was presented.
人防御素是人体内一类阳离子抗菌肽。在过去二十年中，一系列内源性α-和β-人防御素被发现。它们是人体抵御各种微生物入侵的第一道防线的重要组成部分，并且被认为在连接人体的固有防御系统和适应性防御系统中发挥重要作用。本文综述了人防御素研究的最新进展，包括其发现、分子和遗传特性、表达调控以及抗菌活性机制。还讨论了通过基因工程生产人防御素的可能性。并介绍了人防御素在医学以及治疗抗生素耐药微生物感染患者方面的应用前景。
