Bagnicka Emilia, Strzałkowska Nina, Jóźwik Artur, Krzyżewski Józef, Horbańczuk Jarosław, Zwierzchowski Lech
Institute of Genetics and Animal Breeding in Jastrzębiec, Polish Academy of Sciences, Wólka Kosowska, Poland.
Acta Biochim Pol. 2010;57(4):487-97. Epub 2010 Dec 6.
Due to their activity against bacteria, viruses, and fungi, antimicrobial peptides are important factors in the innate resistance system of humans and animals. They are called "new generation antibiotics" for their potential use in preventive and therapeutic medicine. The most numerous group of antimicrobial peptides is a family of cationic peptides which include defensins and cathelicidins. Among them the most common are peptides with a beta-sheet structure containing three intra-molecular disulphide bonds, called defensins, comprising three classes: alpha, beta, and theta. The class of beta-defensins is the largest one. Their transcripts have been found in many tissues of humans and animals. The aim of this paper is to present the current knowledge about antimicrobial peptides from the defensin family in farm animals, their expression, polymorphism, as well as the potential of their use as genetic markers of health and production traits.
由于其对细菌、病毒和真菌的活性，抗菌肽是人和动物先天抵抗系统中的重要因素。因其在预防和治疗医学中的潜在用途，它们被称为“新一代抗生素”。抗菌肽中数量最多的一类是阳离子肽家族，其中包括防御素和cathelicidins。其中最常见的是具有β-折叠结构的肽，含有三个分子内二硫键，称为防御素，包括三类：α、β和θ。β-防御素类别是最大的一类。它们的转录本已在人和动物的许多组织中发现。本文的目的是介绍关于家畜中防御素家族抗菌肽的现有知识、它们的表达、多态性，以及它们作为健康和生产性状遗传标记的潜在用途。
