Perret Emilie, Courjean Olivier, Vigier Sylvain, Feracci Hélène
CNRS UMR144, Institut Curie, Morphogenèse cellulaire et progression tumorale, 26, rue d'Ulm, 75248 Paris.
J Soc Biol. 2004;198(4):357-63.
Cadherins play a major role in the development and maintenance of all solid tissues. These transmembrane glycoproteins are responsible for calcium-dependent homophilic cell interactions. Recently, many different experimental approaches have been used to untangle the molecular basis of cadherin-mediated adherence. Various models have been suggested, particularly from high-resolution structures. Whilst the adherence mechanism is still under controversy, it is widely accepted that the specificity of the adherent interaction is localized to the N-terminal domain. New biophysical techniques together with biological approaches will allow a better understanding of how cadherins regulate cell-cell adherence. Integrating kinetics properties of cadherin interaction at the single molecule level has led to a greater understanding of cadherin molecular regulations.
钙黏着蛋白在所有实体组织的发育和维持中发挥着重要作用。这些跨膜糖蛋白负责钙依赖性的同型细胞相互作用。最近，人们采用了许多不同的实验方法来阐明钙黏着蛋白介导黏附的分子基础。已经提出了各种模型，特别是基于高分辨率结构的模型。虽然黏附机制仍存在争议，但人们普遍认为黏附相互作用的特异性定位于N端结构域。新的生物物理技术与生物学方法将有助于更好地理解钙黏着蛋白如何调节细胞间黏附。整合单分子水平上钙黏着蛋白相互作用的动力学特性，有助于更深入地了解钙黏着蛋白的分子调控。
