Koch A W, Bozic D, Pertz O, Engel J
Department of Biochemistry and Molecular Biology, Mount Sinai School ofMedicine, 1 Gustave L Levy Place, New York, NY 10029, USA.
Curr Opin Struct Biol. 1999 Apr;9(2):275-81. doi: 10.1016/S0959-440X(99)80038-4.
Cadherins mediate cell-cell adhesion through homophilic interactions. High-resolution structures have greatly enhanced our understanding of this phenomenon over the past few years. Nonetheless, some of the original concepts about cadherin interactions need revision, with the new structural and additional mutagenesis data currently available. Furthermore, in vivo studies on cadherins have provided supplementary information.
钙黏蛋白通过同嗜性相互作用介导细胞间黏附。在过去几年中，高分辨率结构极大地增进了我们对这一现象的理解。尽管如此，鉴于目前可获得的新结构数据和更多的诱变数据，一些关于钙黏蛋白相互作用的原始概念需要修正。此外，对钙黏蛋白的体内研究提供了补充信息。
