Perumal Bagavathi S, Sakharkar Kishore R, Chow Vincent Tak Kwong, Pandjassarame Kangueane, Sakharkar Meena Kishore
NCSV, MAE, Nanyang Technological University, 639798, Singapore.
Front Biosci. 2005 Sep 1;10:2412-9. doi: 10.2741/1706.
A compilation of intron positions obtained from a large number of eukaryotic genomes across orthologous tubulins is explored for molecular evolution. Comparison of intron positions for 41 alpha, 80 beta, and 30 gamma tubulin genomic sequences indicates that the putative ancestral tubulin gene contained at least 19, 33, and 52 intron positions distributed at different sites in the coding regions for alpha, beta, and gamma tubulins, respectively. Many intron positions are old and are conserved across different eukaryotic lineages and intron distribution patterns are consistent with 'introns-early' hypothesis.
对从大量真核生物基因组的直系同源微管蛋白中获得的内含子位置进行汇编,以探索分子进化。对41个α-微管蛋白、80个β-微管蛋白和30个γ-微管蛋白基因组序列的内含子位置进行比较,结果表明,推测的祖先微管蛋白基因分别在α、β和γ-微管蛋白编码区的不同位点包含至少19、33和52个内含子位置。许多内含子位置古老且在不同真核生物谱系中保守,内含子分布模式与“内含子早期”假说一致。