欧洲心脏手术风险评估系统(Euroscore)模型在澳大利亚患者群体中的验证。
Validation of Euroscore model in an Australian patient population.
作者信息
Yap Cheng-Hon, Mohajeri Morteza, Ihle Benno U, Wilson Anthony C, Goyal Shiromani, Yii Michael
机构信息
Department of Cardiothoracic Surgery, St Vincent's Hospital in affiliation with Department of Surgery, University of Melbourne, Victoria, Australia.
出版信息
ANZ J Surg. 2005 Jul;75(7):508-12. doi: 10.1111/j.1445-2197.2005.03440.x.
BACKGROUND
The purpose of the present paper was to assess the performance of the European system for cardiac operative risk evaluation (EuroSCORE) model in an Australian adult cardiac surgical population.
METHODS
The additive and logistic EuroSCORE models were retrospectively applied to predict operative mortality in 2106 consecutive patients undergoing cardiac surgery at St Vincent's Hospital, Melbourne between June 2001 and August 2003, and at Geelong Hospital between June 2001 and April 2004. The entire cohort and a subset of patients undergoing isolated coronary artery bypass graft (CABG) surgery were analysed. Model discrimination and calibration was tested by determining the area under the receiver operating characteristic (ROC) curve and Hosmer-Lemeshow chi2, respectively.
RESULTS
There were significant differences in the prevalence of risk factors between the Australian and European cardiac surgical populations. There were 81 deaths (observed mortality 3.85%) in the entire cohort and 39 deaths in the isolated CABG group (observed mortality 2.60%). The EuroSCORE models overestimated mortality (entire cohort: additive predicted 5.75%, logistic predicted 9.93%; isolated CABG: additive predicted 4.87%, logistic predicted 7.71%). Discriminative power was very good for the entire cohort (area under ROC curve, 0.81 (additive) and 0.82 (logistic)). Calibration of both models was poor.
CONCLUSION
The additive and logistic EuroSCORE model of risk prediction was not validated in the present population of cardiac surgical patients. The models may not accurately predict outcomes of patients undergoing cardiac surgery in Australia.
背景
本文旨在评估欧洲心脏手术风险评估(EuroSCORE)模型在澳大利亚成年心脏手术人群中的表现。
方法
回顾性应用累加式和逻辑回归EuroSCORE模型,预测2001年6月至2003年8月在墨尔本圣文森特医院以及2001年6月至2004年4月在吉朗医院连续接受心脏手术的2106例患者的手术死亡率。对整个队列以及接受单纯冠状动脉搭桥术(CABG)的患者子集进行分析。分别通过确定受试者工作特征(ROC)曲线下面积和Hosmer-Lemeshow卡方检验来测试模型的辨别力和校准度。
结果
澳大利亚和欧洲心脏手术人群的危险因素患病率存在显著差异。整个队列中有81例死亡(观察到的死亡率为3.85%),单纯CABG组中有39例死亡(观察到的死亡率为2.60%)。EuroSCORE模型高估了死亡率(整个队列:累加式预测为5.75%,逻辑回归预测为9.93%;单纯CABG:累加式预测为4.87%,逻辑回归预测为7.71%)。整个队列的辨别力非常好(ROC曲线下面积,累加式为0.81,逻辑回归为0.82)。两个模型的校准度都很差。
结论
累加式和逻辑回归EuroSCORE风险预测模型在目前的心脏手术患者人群中未得到验证。这些模型可能无法准确预测澳大利亚接受心脏手术患者的预后。