Wu Jie-Ying, Zhang Yi
Guangzhou Maternal and Neonatal Hospital, Guangzhou Cord Blood Bank, Guangzhou 510180, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Jun;13(3):514-7.
Recently mesenchymal stem cells have been successfully obtained from various sources of human body, including bone marrow, compact bone, peripheral blood, adipose tissue, cord blood, amniotic fluid and other fetal tissues. Placenta, as a temporary organ keeping substance exchange between mother and fetus, consisted of decidua basalis and chorion frondosum, which derived from cytotrophoblast and extraembryonic mesoderm, thus involved both primary embryonic cells and adult stem cells. As a castoff after parturition, along with the ease of accessibility, lack of ethical concerns, placenta may be an attractive source of mesenchymal stem/progenitor cells for basic and clinical application. Therefore, the origin, isolation, characteristics and potential uses in future therapy are mainly reviewed in this paper.
最近，间充质干细胞已成功从人体的各种来源获得，包括骨髓、致密骨、外周血、脂肪组织、脐带血、羊水和其他胎儿组织。胎盘作为维持母体与胎儿之间物质交换的临时器官，由基蜕膜和叶状绒毛膜组成，它们分别来源于细胞滋养层和胚外中胚层，因此既包含原始胚胎细胞又包含成体干细胞。作为分娩后的废弃物，随着获取的便利性以及不存在伦理问题，胎盘可能是用于基础和临床应用的间充质干/祖细胞的一个有吸引力的来源。因此，本文主要综述了其来源、分离方法、特性以及在未来治疗中的潜在用途。
