肠致病性大肠杆菌III型效应蛋白EspG和EspG2破坏肠上皮细胞的微管网络。
Enteropathogenic Escherichia coli type III effectors EspG and EspG2 disrupt the microtubule network of intestinal epithelial cells.
作者信息
Shaw Robert K, Smollett Katherine, Cleary Jennifer, Garmendia Junkal, Straatman-Iwanowska Ania, Frankel Gad, Knutton Stuart
机构信息
Institute of Child Health, University of Birmingham, Whittall St., Birmingham B4 6NH, United Kingdom.
出版信息
Infect Immun. 2005 Jul;73(7):4385-90. doi: 10.1128/IAI.73.7.4385-4390.2005.
Abstract
Enteropathogenic Escherichia coli infection of intestinal epithelial cells leads to localized depletion of the microtubule cytoskeleton, an effect that is dependent on delivery of type III translocated effector proteins EspG and Orf3 (designated EspG2) to the site of depletion. Microtubule depletion involved disruption rather than displacement of microtubules.
摘要
肠道致病性大肠杆菌感染肠道上皮细胞会导致微管细胞骨架局部耗竭，这种效应依赖于III型易位效应蛋白EspG和Orf3（命名为EspG2）传递至耗竭位点。微管耗竭涉及微管的破坏而非移位。
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