Edison Lekshmi K, Kudva Indira T, Kariyawasam Subhashinie
Department of Comparative, Diagnostic, and Population Medicine, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Food Safety and Enteric Pathogens Research Unit, National Animal Disease Center, Agricultural Research Service, United States Department of Agriculture, Ames, IA 50010, USA.
Microorganisms. 2024 Oct 3;12(10):2009. doi: 10.3390/microorganisms12102009.
Shiga toxin-producing (STEC) is a significant public health threat due to its ability to cause severe gastrointestinal diseases in humans, ranging from diarrhea to life-threatening conditions such as hemorrhagic colitis and hemolytic uremic syndrome (HUS). As the primary reservoir of STEC, cattle play a crucial role in its transmission through contaminated food and water, posing a considerable risk to human health. This comprehensive review explores host-pathogen interactions during STEC colonization of the bovine gut, focusing on the role of gut microbiota in modulating these interactions and influencing disease outcomes. We integrated findings from published transcriptomics, proteomics, and genomics studies to provide a thorough understanding of how STEC adheres to and colonizes the bovine gastrointestinal tract. The insights from this review offer potential avenues for the development of novel preventative and therapeutic strategies aimed at controlling STEC colonization in cattle, thereby reducing the risk of zoonotic transmission.
产志贺毒素大肠杆菌（STEC）对公众健康构成重大威胁，因为它能够在人类中引发严重的胃肠道疾病，从腹泻到诸如出血性结肠炎和溶血尿毒综合征（HUS）等危及生命的病症。作为STEC的主要宿主，牛在通过受污染的食物和水传播该病菌方面起着关键作用，对人类健康构成相当大的风险。这篇综述全面探讨了STEC在牛肠道定殖过程中的宿主-病原体相互作用，重点关注肠道微生物群在调节这些相互作用以及影响疾病结果方面的作用。我们整合了已发表的转录组学、蛋白质组学和基因组学研究结果，以全面了解STEC如何附着并定殖于牛的胃肠道。这篇综述所得出的见解为开发旨在控制牛体内STEC定殖的新型预防和治疗策略提供了潜在途径，从而降低人畜共患病传播的风险。
