Arora Shiwani K, Neely Alice N, Blair Barbara, Lory Stephen, Ramphal Reuben
Department of Medicine/Infectious Diseases, P.O. Box 100277, University of Florida, Gainesville, Florida 32610, USA.
Infect Immun. 2005 Jul;73(7):4395-8. doi: 10.1128/IAI.73.7.4395-4398.2005.
In this study, we tested the contribution of flagellar motility, flagellin structure, and its glycosylation in Pseudomonas aeruginosa using genetically defined flagellar mutants. All mutants and their parent strains were tested in a burned-mouse model of infection. Motility and glycosylation of the flagellum appear to be important determinants of flagellar-mediated virulence in this model. This is the first report where genetically defined flagellar variants of P. aeruginosa were tested in the burned-mouse model of infection.
在本研究中,我们使用基因定义的鞭毛突变体测试了铜绿假单胞菌中鞭毛运动性、鞭毛蛋白结构及其糖基化的作用。所有突变体及其亲本菌株均在烧伤小鼠感染模型中进行了测试。在该模型中,鞭毛的运动性和糖基化似乎是鞭毛介导的毒力的重要决定因素。这是首次在烧伤小鼠感染模型中对基因定义的铜绿假单胞菌鞭毛变体进行测试的报告。