Penack Olaf, Keilholz Ullrich, Thiel Eckhard, Blau Igor Wolfgang
Department of Hematology, Oncology, and Transfusion Medicine, Charité-Campus Benjamin Franklin, Berlin, Germany.
Jpn J Infect Dis. 2005 Jun;58(3):171-3.
In this prospective pilot study we evaluated the efficacy of blood cultures (BC) in detecting bacteremia and fungemia prior to the occurrence of infectious signs. Between February 2003 and July 2003, BC were performed twice weekly in neutropenic hematological patients using blood drawn from central venous catheters. Microbial growth prior to the onset of infectious symptoms was detected in 3 of 45 neutropenic episodes in 39 patients and led to modifications in patient management. These results suggest that further prospective studies are warranted to determine the clinical usefulness of surveillance with BC in neutropenic patients.
在这项前瞻性试点研究中，我们评估了血培养（BC）在感染症状出现之前检测菌血症和真菌血症的功效。2003年2月至2003年7月期间，对中性粒细胞减少的血液病患者每周进行两次血培养，使用从中心静脉导管抽取的血液。在39例患者的45次中性粒细胞减少发作中，有3次在感染症状出现之前检测到微生物生长，这导致了患者管理的调整。这些结果表明，有必要进行进一步的前瞻性研究，以确定对中性粒细胞减少患者进行血培养监测的临床实用性。
