毒蕈碱受体的变构效应：配体与机制

Allosterism at muscarinic receptors: ligands and mechanisms.

作者信息

Birdsall N J M, Lazareno S

机构信息

Division of Physical Biochemistry, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.

出版信息

Mini Rev Med Chem. 2005 Jun;5(6):523-43. doi: 10.2174/1389557054023251.

DOI:10.2174/1389557054023251

PMID:15974931

Abstract

The evaluation of allosteric ligands at muscarinic receptors is discussed in terms of the ability of the experimental data to be interpreted by the allosteric ternary complex model. The compilation of useful SAR information of allosteric ligands is not simple, especially for muscarinic receptors, where there are multiple allosteric sites and complex interactions.

摘要

从变构三元复合物模型对实验数据的解释能力方面，讨论了毒蕈碱受体变构配体的评估。变构配体有用的构效关系（SAR）信息的汇编并不简单，尤其是对于毒蕈碱受体而言，其存在多个变构位点且相互作用复杂。