Serrao Sebastiano, Lombardo Marco
Serraolaser, Rome, Italy.
J Cataract Refract Surg. 2005 May;31(5):930-7. doi: 10.1016/j.jcrs.2004.12.041.
To characterize the velocity of epithelial migration after photorefractive keratectomy (PRK) with 3 different corneal ablation patterns.
Department of Ophthalmology, Catholic University of Rome, Rome, Italy.
Fifteen patients (30 eyes) with mild to moderate myopia and with simple to compound myopic astigmatism were enrolled for this study. The surgical procedure consisted of standardized PRK with final smoothing performed using the Technolas Keracor 217C excimer laser. The reepithelialization process was evaluated at 0 hours, 20 hours, 40 hours, and 60 hours after surgery using a digital photo camera and custom software for measurement. Digital analysis of the images was performed. Corneal topographies were taken at 1 month, 3 months, 6 months, and 12 months after PRK.
The mean speed of radial migration in the 10 eyes (33%) in the low spherical ablation group was 0.087 mm/h +/- 0.008 (SD). This was significantly higher than that found in the 10 eyes (33%) in the high spherical ablation group (mean speed 0.078 +/- 0.007 mm/h; P<.001) and in the 10 eyes (33%) in the cross-cylinder ablation group (mean speed 0.055 +/- 0.014 mm/h; P<.001).
Analysis of the data shows that epithelial migration along the photoablated corneal surface depends on the ablation pattern. The epithelial sliding is highly influenced by local variations in the curvature of the stromal surface. The data demonstrate that faster epithelial wound healing after PRK is predictive of optimal visual performance.
通过3种不同的角膜消融模式来描述准分子激光原位角膜磨镶术（PRK）后上皮迁移的速度。
意大利罗马天主教大学眼科。
15例（30只眼）轻度至中度近视合并单纯性至复合性近视散光患者纳入本研究。手术过程包括使用Technolas Keracor 217C准分子激光进行标准化PRK及最后的表面光滑处理。术后0小时、20小时、40小时和60小时使用数码相机和定制测量软件评估上皮再形成过程。对图像进行数字分析。PRK术后1个月、3个月、6个月和12个月进行角膜地形图检查。
低球镜消融组10只眼（33%）的平均径向迁移速度为0.087 mm/h±0.008（标准差）。这显著高于高球镜消融组10只眼（33%）（平均速度0.078±0.007 mm/h；P<0.001）和交叉柱镜消融组10只眼（33%）（平均速度0.055±0.014 mm/h；P<0.001）。
数据分析表明，光凝角膜表面的上皮迁移取决于消融模式。上皮滑动受基质表面曲率局部变化的高度影响。数据表明，PRK术后更快的上皮伤口愈合可预测最佳视觉性能。
