Chiaffarino Francesca, Pelucchi Claudio, Negri Eva, Parazzini Fabio, Franceschi Silvia, Talamini Renato, Montella Maurizio, Ramazzotti Valerio, La Vecchia Carlo
Istituto di Ricerche Farmacologiche "Mario Negri", Via Eritrea, 62-20157 Milan, Italy.
Gynecol Oncol. 2005 Aug;98(2):304-8. doi: 10.1016/j.ygyno.2005.05.006.
Breastfeeding has been inversely related to the risk of ovarian cancer, but results from published studies are inconsistent. In order to provide further information, we analyzed data from a large case-control study conducted in four Italian areas.
Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer.
There were inverse trends in risk with increasing duration of breastfeeding and number of children breastfed, but when parity and several other potential confounding factors were taken into account, no residual association was evident (odds ratio = 1.21 for 17 or more months of breastfeeding and 0.90 for those who had breastfed 4 or more children, as compared to women who had never breastfed).
This study showed an inverse relation between breastfeeding and ovarian cancer risk, which however was accounted for by parity. The analyses by histologic subtypes suggested that a role of breastfeeding would be larger for serous neoplasms in the absence, however, of significant heterogeneity.
母乳喂养与卵巢癌风险呈负相关，但已发表研究的结果并不一致。为了提供更多信息，我们分析了在意大利四个地区进行的一项大型病例对照研究的数据。
病例为1031例上皮性卵巢癌女性。对照为2411名因各种急性非肿瘤性疾病入住同一医院网络的女性，这些疾病与已知的卵巢癌危险因素无关。
随着母乳喂养持续时间的延长和母乳喂养子女数的增加，风险呈负向趋势，但在考虑产次和其他几个潜在混杂因素后，未发现明显的残余关联（与从未母乳喂养的女性相比，母乳喂养17个月或更长时间的女性的优势比为1.21，母乳喂养4个或更多子女的女性的优势比为0.90）。
本研究显示母乳喂养与卵巢癌风险之间存在负相关，但这一关系可由产次解释。按组织学亚型分析表明，母乳喂养对浆液性肿瘤的作用可能更大，然而，不存在显著的异质性。
