Puthenveedu Manojkumar A, Linstedt Adam D
Department of Psychiatry, University of California-San Francisco, San Francisco, CA, USA.
Curr Opin Cell Biol. 2005 Aug;17(4):369-75. doi: 10.1016/j.ceb.2005.06.006.
The subcompartmentalized structure of the Golgi apparatus contributes to efficient glycosylation in the secretory pathway. Subcompartmentalization driven by maturation relies primarily on constant and accurate vesicle-mediated local recycling of Golgi residents. The precision of this vesicle transport is dependent on the interplay between the key factors that mediate vesicle budding and fusion--the coat proteins and the SNARE fusion machinery. These alone, however, may not be sufficient to ensure establishment of compartments de novo, and additional regulatory mechanisms operate to modify their activity.
高尔基体的亚区室化结构有助于分泌途径中的高效糖基化。由成熟驱动的亚区室化主要依赖于高尔基体驻留蛋白通过囊泡介导的持续且精确的局部循环。这种囊泡运输的精确性取决于介导囊泡出芽和融合的关键因子——衣被蛋白和SNARE融合机制之间的相互作用。然而，仅这些可能不足以确保从头建立区室，还需要额外的调节机制来改变它们的活性。
