Manabe Kei, Nobutou Daisuke, Kobayashi Shū
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Bioorg Med Chem. 2005 Sep 1;13(17):5154-8. doi: 10.1016/j.bmc.2005.05.018.
The catalytic Pictet-Spengler reactions proceeded in high yields with high regioselectivity in the presence of a catalytic amount of Yb(OTf)3 and a dehydrating agent at room temperature. High regioselectivities were obtained in these reactions, and it is suggested that the reactions proceeded under kinetic control.
在催化量的Yb(OTf)₃和脱水剂存在下，催化Pictet-Spengler反应在室温下以高收率和高区域选择性进行。这些反应获得了高区域选择性，表明反应是在动力学控制下进行的。
