Escher P, Lacazette E, Courtet M, Blindenbacher A, Landmann L, Bezakova G, Lloyd K C, Mueller U, Brenner H R
Institute of Physiology, Biozentrum, University of Basel, 4056 Basel, Switzerland.
Science. 2005 Jun 24;308(5730):1920-3. doi: 10.1126/science.1108258.
The formation of the neuromuscular junction (NMJ) is directed by reciprocal interactions between motor neurons and muscle fibers. Neuregulin (NRG) and Agrin from motor nerve terminals are both implicated. Here, we demonstrate that NMJs can form in the absence of the NRG receptors ErbB2 and ErbB4 in mouse muscle. Postsynaptic differentiation is, however, induced by Agrin. We therefore conclude that NRG signaling to muscle is not required for NMJ formation. The effects of NRG signaling to muscle may be mediated indirectly through Schwann cells.
神经肌肉接头（NMJ）的形成由运动神经元和肌纤维之间的相互作用所引导。运动神经末梢分泌的神经调节蛋白（NRG）和聚集蛋白都与之相关。在此，我们证明在小鼠肌肉中，即使没有NRG受体ErbB2和ErbB4，神经肌肉接头也能形成。然而，突触后分化是由聚集蛋白诱导的。因此，我们得出结论，神经肌肉接头的形成并不需要NRG向肌肉的信号传导。NRG向肌肉的信号传导作用可能是通过雪旺细胞间接介导的。
