中国I型人类嗜T细胞病毒的流行情况及部分序列分析
Prevalence and partial sequence analysis of human T cell lymphotropic virus type I in China.
作者信息
Wang Youchun, Li Xiouhua, Song Aijing, Zhang Chuntao, Chen Ying, Chen Changrong, Lin Yisheng, Shun Liping, Li Luilan, Liu Yanchun, Yang Jian, Yang Bowei, Tang Qiouping, Harrison Tim J
机构信息
Department of Cell Biology, National Institute for the Control of Pharmaceutical and Biological Products, Beijing, China.
出版信息
J Med Virol. 2005 Aug;76(4):613-8. doi: 10.1002/jmv.20405.
A total of 145,293 serum samples were collected from volunteer blood donors in 13 provinces of China and tested for anti-HTLV antibody using an ELISA licensed in China. Thirty were positive for anti-HTLV by ELISA and 19 of those 30 samples were confirmed positive using a supplemental immunoblot assay. Anti-HTLV-I was detected only in samples from Fujian province (a Southern province) where the positivity rate was approximately 0.05%. The region encoding gp46 from 5 of the 19 antibody positive samples was amplified and sequenced. Sequence analysis indicated that these isolates belong to HTLV-I genotype A. These data suggest that HTLV-I is not endemic throughout China and the virus may be restricted to a particular region.
在中国13个省份，共采集了145,293份来自无偿献血者的血清样本，并使用中国许可的酶联免疫吸附测定法（ELISA）检测抗人类嗜T淋巴细胞病毒（HTLV）抗体。通过ELISA检测，有30份样本抗HTLV呈阳性，其中19份样本经补充免疫印迹法确认为阳性。仅在福建省（中国南方省份）的样本中检测到抗HTLV-I，其阳性率约为0.05%。对19份抗体阳性样本中的5份样本编码gp46的区域进行了扩增和测序。序列分析表明，这些分离株属于HTLV-I A基因型。这些数据表明，HTLV-I在中国并非地方性流行，该病毒可能局限于特定区域。
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