O'Connor M K, Cho D S
Department of Radiology, Mayo Clinic, Rochester, Minnesota.
J Nucl Med. 1992 Jun;33(6):1146-51.
Technetium-99m-teboroxime demonstrates high extraction and rapid washout from the myocardium. To evaluate the feasibility of performing SPECT with this agent using a single-headed gamma camera system, a series of phantom studies were performed that simulated varying degrees of washout from normal and "ischemic" regions of the myocardium. In the absence of ischemic regions, short axis profiles were relatively unaffected by washout of less than 50% of activity over the duration of a SPECT acquisition. However, significant corruption of the SPECT data was observed when large (greater than a factor of 2) differences existed in the washout of activity from normal and "ischemic" myocardium. This corruption was observed with 30%-40% washout of activity from normal regions of the heart. Based on published washout rates, these results indicate that clinical studies with 99mTc-teboroxime may need to be completed within 2-4 min to order to prevent degradation of image quality due to differential washout effects.
锝-99m-特硼肟从心肌中显示出高摄取率和快速洗脱。为了评估使用单头伽马相机系统用该试剂进行单光子发射计算机断层扫描（SPECT）的可行性，进行了一系列体模研究，模拟了心肌正常区域和“缺血”区域不同程度的洗脱情况。在没有缺血区域的情况下，短轴剖面图在SPECT采集期间活性洗脱小于50%时相对不受影响。然而，当正常心肌和“缺血”心肌的活性洗脱存在较大差异（大于2倍）时，观察到SPECT数据有明显破坏。当心脏正常区域活性洗脱30%-40%时观察到这种破坏。根据已发表的洗脱率，这些结果表明，用锝-99m-特硼肟进行的临床研究可能需要在2-4分钟内完成，以防止由于差异洗脱效应导致图像质量下降。
