Ajani E O, Salau B A, Fagbohun T R, Ogun A O
Department of Biochemistry, Olabisi Onabanjo University, Ago-Iwoye, Nigeria.
Afr J Med Med Sci. 2004 Dec;33(4):365-9.
Effect of combined administration of Insulin and Chloroquine on fasting blood glucose, total protein, creatinine and uric acid concentration were investigated in rats placed on diets high in fat and calcium (SP diet). Thirty-six (36) rats (grouped into six) were placed on different treatment: Grams A and B were fed with NP (normal diet) and SP diet respectively; Group C was placed on NP diet and injected intramuscularly with 100 microg insulin per day; Group D was placed on SP diet and also injected with 100 microg insulin per day; Group E was placed on SP diet and injected with both insulin (100 microg/day) and chloroquine (20mg/Kg thrice weekly); Group F was placed on SP diet and injected with chloroquine (20mg/Kg) thrice weekly. After 15 weeks of treatment, a significantly reduced concentration of glucose was observed in groups injected with insulin and those injected with insulin and chloroquine together (compared with the control groups, A and B). The serum total protein and uric acid level were however not significantly different in all the rats. Serum creatinine was also observed to be significantly lowered in the rats treated with insulin. The results of this study thus suggest that insulin and chloroquine administration may result in reduced blood glucose level (hypoglycemia). It also suggests that insulin and chloroquine administration may further effect an improved kidney function.
在喂食高脂肪和高钙饮食（SP 饮食）的大鼠中，研究了胰岛素和氯喹联合给药对空腹血糖、总蛋白、肌酐和尿酸浓度的影响。三十六只大鼠（分为六组）接受不同治疗：A 组和 B 组分别喂食正常饮食（NP）和 SP 饮食；C 组喂食 NP 饮食，每天肌肉注射 100 微克胰岛素；D 组喂食 SP 饮食，也每天注射 100 微克胰岛素；E 组喂食 SP 饮食，同时注射胰岛素（100 微克/天）和氯喹（20 毫克/千克，每周三次）；F 组喂食 SP 饮食，每周三次注射氯喹（20 毫克/千克）。治疗 15 周后，注射胰岛素的组以及同时注射胰岛素和氯喹的组中观察到葡萄糖浓度显著降低（与对照组 A 和 B 相比）。然而，所有大鼠的血清总蛋白和尿酸水平没有显著差异。在用胰岛素治疗的大鼠中还观察到血清肌酐显著降低。因此，本研究结果表明，胰岛素和氯喹给药可能导致血糖水平降低（低血糖）。这也表明，胰岛素和氯喹给药可能进一步改善肾功能。
